Completed Studies

Mechanisms and Effects of Oxytocin on Social Cognition in Schizophrenia - fMRI

Adult Oxytocin Study - Functional Magnetic Resonance Imaging (fMRI)

The purpose of this study was to investigate how oxytocin affects brain functions that are related to social deficits in recent-onset schizophrenia.

 

Effects of Oyxotocin on Familial Interactions

Dyad Oxytocin Study (DOS)

The purpose of this study was to test the effects of oxytocin on interactions in families with a child with a psychotic illness or autism spectrum disorder.

 

The effects of intranasal oxytocin on social cognition and social approach behaviors in opiod-dependent patients

Methadone Oxytocin Option (MOO)

This proof-of-concept pilot study was designed to examine the effects of oxytocin in individuals with opioid dependence receiving opioid replacement therapy (ORT) and healthy control subjects. We examined whether oxytoxin is safe to give in our clinical popular and whether oxytocin could be a useful adjuct treatment for sufferers of opioid dependence. Specifical, we examined oxytocin's ability to reduce drug seeking behaviors such as impulsivity and craving and improve social perception.

Preliminary findings from MOO were presented at the American College of Neuropsychopharmacology (ACNP) Annual Meeting in Decemeber of 2014.

 

Chronic intranasal oxytocin as an adjunct to methadone maintenance treatment in patients with occurring opioid use disorder and cocaine use: A 2-week pilot study 

Cocaine Opiod Oxytocin Option Limited (COOOL) 

This pilot feasibility study is a randomized, placebo-controlled, double-blinded clinical trial of tolerability and efficacy of chronic oxytocin administration in 22 patients at the San Francisco General Hospital Opiate Treatment Outpatient Program receiving opioid replacement therapy who are actively using cocaine. This study is a critical next step toward developing oxytocin as an adjunct treatment for substance use disorders by way of a larger clinical trial.

Preliminary findings for COOOL were presented at the Society of Biological Psychiatry (SOBP) Annual Meeting in May of 2015.

 

Optimizing Cognitive Remediation Outcomes in Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder with Psychotic Symptoms

Feasibility of Remote Exercises for Cognitive and Social Training (FORECAST)

The purpose of this study was to investigate the feasibility of remote neuroplasticity-based cognitive remediation.  In our study, participants completed 80 hours of cognitive training exercise from their homes using study-provided iPads instead of having to regularly travel to the study site. 

 

CLIMB: A Mobile Intervention for Chronic Psychosis (CLIMB)

The purpose of this project was to deliver a suite of digital diagnostic and treatment tools called CLIMB to individuals with psychosis remotely using iPads and to investigate CLIMB’s effects on social cognition, social functioning, and quality of life. The package of innovative and evidence-based diagnostic and treatment tools included a neuroscience-informed computerized cognitive training program, group tele-therapy, and peer-to-peer secure social networking. The duration of the intervention was approximately 8-10 weeks

 

Effects of Oxytocin on Neural Activation Patterns During Social Cognitive Tasks in Patients with Schizophrenia (MEG)

The purpose of this project was to investigate the neural mechanisms of oxytocin’s prosocial effects in patients with schizophrenia.  We used magnetoencephalography-based imaging (MEG) to elucidate the neural mechanisms of oxytocin’s prosocial effects on critical social cognitive processes.